In November 1971, Intel introduced the world’s first single-chip microprocessor, the Intel 4004. It had 2,300 transistors, ran at a clock speed of up to 740 KHz, and delivered 60,000 instructions per second while dissipating 0.5 watts. The following four decades witnessed exponential growth in compute power, a trend that has enabled applications as diverse as climate modeling, protein folding, and computing real-time ballistic trajectories of angry birds. Today’s microprocessor chips employ billions of transistors, include multiple processor cores on a single silicon die, run at clock speeds measured in gigahertz, and deliver more than 4 million times the performance of the original 4004. Where did these incredible gains come from? This article sheds some light on this question by introducing CPU DB (cpudb.stanford.edu), an open and extensible database collected by Stanford’s VLSI (very large-scale integration) Research Group over several generations of processors (and students). We gathered information on commercial processors from 17 manufacturers and placed it in CPU DB, which now contains data on 790 processors spanning the past 40 years.